diff --git a/gnu/local.mk b/gnu/local.mk
index d4019b94f1..67be78e17d 100644
--- a/gnu/local.mk
+++ b/gnu/local.mk
@@ -1579,7 +1579,8 @@ dist_patch_DATA =						\
   %D%/packages/patches/gtk3-respect-GUIX_GTK3_PATH.patch	\
   %D%/packages/patches/gtk3-respect-GUIX_GTK3_IM_MODULE_FILE.patch \
   %D%/packages/patches/gtk-doc-respect-xml-catalog.patch	\
-  %D%/packages/patches/gtk-doc-mkhtml-test-fix.patch	\
+  %D%/packages/patches/gtk-doc-mkhtml-test-fix.patch	        \
+  %D%/packages/patches/gtk4-needs-udmabuf.patch                 \
   %D%/packages/patches/gtk4-respect-GUIX_GTK4_PATH.patch    	\
   %D%/packages/patches/gtkglext-disable-disable-deprecated.patch \
   %D%/packages/patches/gtksourceview-2-add-default-directory.patch \
diff --git a/gnu/packages/gtk.scm b/gnu/packages/gtk.scm
index a639dfe55b..21ee73c268 100644
--- a/gnu/packages/gtk.scm
+++ b/gnu/packages/gtk.scm
@@ -1123,7 +1123,7 @@ application suites.")
 (define-public gtk
   (package
     (name "gtk")
-    (version "4.20.3")
+    (version "4.22.1")
     (source
      (origin
        (method url-fetch)
@@ -1131,9 +1131,10 @@ application suites.")
                            (version-major+minor version)  "/"
                            name "-" version ".tar.xz"))
        (sha256
-        (base32 "0ly1gqc6ybxv5f2a9hvjp5k6l9mfzy2yv8iy2xqnr9l8628g4wr8"))
+        (base32 "1z2mkmazc2d51jbg3qwwdycycqiwswm88nhw6bxscz8j86f5lyyd"))
        (patches
-        (search-patches "gtk4-respect-GUIX_GTK4_PATH.patch"))
+        (search-patches "gtk4-needs-udmabuf.patch"
+                        "gtk4-respect-GUIX_GTK4_PATH.patch"))
        (modules '((guix build utils)))))
     (build-system meson-build-system)
     (outputs '("out" "bin" "doc"))
@@ -1257,8 +1258,10 @@ application suites.")
               (setenv "XDG_CACHE_HOME" (getcwd))))
           (add-before 'check 'pre-check
             (lambda* (#:key inputs #:allow-other-keys)
-              ;; Tests require a running X server.
-              (system "Xvfb :1 +extension GLX &")
+              ;; Tests require a running X server.  The '-noreset' option is
+              ;; necessary to avoid spurious "Failed to open display" test
+              ;; errors.
+              (system "Xvfb :1 +extension GLX -screen 0 1024x768x24 -noreset &")
               (setenv "DISPLAY" ":1")
               ;; Tests write to $HOME.
               (setenv "HOME" (getcwd))
@@ -1301,6 +1304,7 @@ application suites.")
            docbook-xsl
            gettext-minimal
            `(,glib "bin")
+           glibc-utf8-locales           ;some tests require en_US.UTF-8
            gobject-introspection        ;for building introspection data
            graphene
            gtk-doc/stable               ;for building documentation
@@ -1368,8 +1372,8 @@ application suites.")
     (native-search-paths
      (list
       (search-path-specification
-       (variable "GUIX_GTK4_PATH")
-       (files '("lib/gtk-4.0")))))
+        (variable "GUIX_GTK4_PATH")
+        (files '("lib/gtk-4.0")))))
     (search-paths native-search-paths)
     (home-page "https://www.gtk.org/")
     (synopsis "Cross-platform widget toolkit")
diff --git a/gnu/packages/patches/gtk-needs-udmabuf.patch b/gnu/packages/patches/gtk-needs-udmabuf.patch
new file mode 100644
index 0000000000..7a261ed3ac
--- /dev/null
+++ b/gnu/packages/patches/gtk-needs-udmabuf.patch
@@ -0,0 +1,35 @@
+Some udmapbuf relying tests were still selected despite using --no-suite=needs-udmabuf.
+
+Upstream-status: Patch prepared by upstream, not yet committed.
+
+diff --git a/testsuite/gsk/meson.build b/testsuite/gsk/meson.build
+index 0118304bf8..6bf4d4bb93 100644
+--- a/testsuite/gsk/meson.build
++++ b/testsuite/gsk/meson.build
+@@ -275,6 +275,16 @@ compare_render_tests = [
+   'zero-length-path-stroke',
+ ]
+ 
++# These tests use dmabufs and fail in testrunners that have
++# dmabuf support but no access to /dev/udmabuf.
++# For that purpose we add them to the 'needs-udmabuf' suite
++# with this list
++needs_udmabuf = [
++  'yuv-matrix-dmabuf-nv12',
++  'yuv-matrix-dmabuf-rgba',
++  'yuv-matrix-dmabuf-yuyv',
++]
++
+ # These tests are either slow or need lots of memory.
+ # So we don't run them in parallel with other such tests to not
+ # cause CI failures
+@@ -386,6 +396,9 @@ foreach renderer : renderers
+         if test_xfails.contains(variant) or (renderer_name == 'cairo' and variant == 'clip')
+           extra_suites += ['failing']
+         endif
++        if needs_udmabuf.contains(testname)
++          extra_suites += ['needs-udmabuf']
++        endif
+         test('compare ' + renderer_name + ' ' + testname + ' ' + variant, compare_render,
+           protocol: 'tap',
+           args: [
diff --git a/gnu/packages/patches/gtk4-needs-udmabuf.patch b/gnu/packages/patches/gtk4-needs-udmabuf.patch
new file mode 100644
index 0000000000..7a261ed3ac
--- /dev/null
+++ b/gnu/packages/patches/gtk4-needs-udmabuf.patch
@@ -0,0 +1,35 @@
+Some udmapbuf relying tests were still selected despite using --no-suite=needs-udmabuf.
+
+Upstream-status: Patch prepared by upstream, not yet committed.
+
+diff --git a/testsuite/gsk/meson.build b/testsuite/gsk/meson.build
+index 0118304bf8..6bf4d4bb93 100644
+--- a/testsuite/gsk/meson.build
++++ b/testsuite/gsk/meson.build
+@@ -275,6 +275,16 @@ compare_render_tests = [
+   'zero-length-path-stroke',
+ ]
+ 
++# These tests use dmabufs and fail in testrunners that have
++# dmabuf support but no access to /dev/udmabuf.
++# For that purpose we add them to the 'needs-udmabuf' suite
++# with this list
++needs_udmabuf = [
++  'yuv-matrix-dmabuf-nv12',
++  'yuv-matrix-dmabuf-rgba',
++  'yuv-matrix-dmabuf-yuyv',
++]
++
+ # These tests are either slow or need lots of memory.
+ # So we don't run them in parallel with other such tests to not
+ # cause CI failures
+@@ -386,6 +396,9 @@ foreach renderer : renderers
+         if test_xfails.contains(variant) or (renderer_name == 'cairo' and variant == 'clip')
+           extra_suites += ['failing']
+         endif
++        if needs_udmabuf.contains(testname)
++          extra_suites += ['needs-udmabuf']
++        endif
+         test('compare ' + renderer_name + ' ' + testname + ' ' + variant, compare_render,
+           protocol: 'tap',
+           args: [