diff --git a/gnu/packages/python-compression.scm b/gnu/packages/python-compression.scm
index d38a98d14d..a2e47ae925 100644
--- a/gnu/packages/python-compression.scm
+++ b/gnu/packages/python-compression.scm
@@ -289,11 +289,13 @@ were a single file.")
     (build-system pyproject-build-system)
     (arguments
      (list
-      ;; tests: 743 passed, 1 skipped, 1 deselected
+      ;; tests: 742 passed, 1 skipped, 2 deselected
       #:test-flags
       #~(list "--ignore=benchmarks/test_bench.py"
               ;; FIXME: Did not raise cramjam.DecompressionError
-              "--deselect=tests/test_variants.py::test_variants_raise_exception[deflate]")
+              "--deselect=tests/test_variants.py::test_variants_raise_exception[deflate]"
+              ;; This test fails nondeterministically.
+              "--deselect=tests/test_variants.py::test_variants_decompress_into[zlib-Buffer-File]")
       #:imported-modules `(,@%cargo-build-system-modules
                            ,@%pyproject-build-system-modules)
       #:modules '(((guix build cargo-build-system) #:prefix cargo:)