diff --git a/gnu/packages/bioconductor.scm b/gnu/packages/bioconductor.scm
index f03c171e962..1e5ba064f7c 100644
--- a/gnu/packages/bioconductor.scm
+++ b/gnu/packages/bioconductor.scm
@@ -23554,14 +23554,14 @@ populations, splice site strength, conservation, etc.")
 (define-public r-variancepartition
   (package
     (name "r-variancepartition")
-    (version "1.40.2")
+    (version "1.42.0")
     (source
      (origin
        (method url-fetch)
        (uri (bioconductor-uri "variancePartition" version))
        (sha256
         (base32
-         "0k2rcgg4ll06b9j7999d4l60wpmi3vnjaqiy5ay8ppd1z0m38ygf"))))
+         "00p8nw13fm46r1mw1mavnk2pycxycqgj7lhric8rawxsk186wq6w"))))
     (properties
      '((upstream-name . "variancePartition")
        (updater-extra-native-inputs . ("r-rfast"))))