diff --git a/gnu/packages/bioconductor.scm b/gnu/packages/bioconductor.scm
index 1ac47df49ed..d8e3ee10851 100644
--- a/gnu/packages/bioconductor.scm
+++ b/gnu/packages/bioconductor.scm
@@ -20531,14 +20531,14 @@ based on @dfn{Continuous Wavelet Transform} (CWT).")
 (define-public r-xcms
   (package
     (name "r-xcms")
-    (version "4.4.0")
+    (version "4.6.0")
     (source
      (origin
        (method url-fetch)
        (uri (bioconductor-uri "xcms" version))
        (sha256
         (base32
-         "1i9xiilrwvnzkdbzrdnbsw0sbwplfaklbsk3wz8kzv87ivipybh5"))))
+         "1yf5x69f7m8bqassxzzhys7gbnvsyw79b13xlib156abyjvr5g2b"))))
     (properties
      '((upstream-name . "xcms")
        ;; Avoid dependency cycle.